Thrombin activatable fibrinolysis inhibitor (TAFI) and the risk of recurrent venous thromboembolism
نویسندگان
چکیده
From the Department of Internal Medicine I, Div. of Hematology/Hemostasis (SE, VS, AW, PAK), the Ludwig-Boltzmann Institute for Thrombosis Research (SE, PAK), and the Department of Internal Medicine II, Div. of Angiology (EM), all University of Vienna, Vienna; the Wilhelminenspital, Department of Dermatology (CB), Vienna; the Hanuschkrankenhaus, Department of Angiology (MH), Vienna; the Institute of Medical Statistics (BS), and the Clinical Institute of Chemical and Laboratory Diagnostics (PQ), University of Vienna; Vienna; all Austria
منابع مشابه
Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism.
BACKGROUND AND OBJECTIVES The clinical expression of factor V Leiden varies widely within and between families and only a minority of carriers will ever develop venous thromboembolism. Co-segregation of thrombophilic disorders is a possible explanation. Our aim was to assess the contributions of high levels of factor VIII:C, factor XI:C, thrombin activatable fibrinolysis inhibitor (TAFI) and li...
متن کاملScientific Heading: Hemostasis, Thrombosis, and Vascular Biology Thrombin activatable fibrinolysis inhibitor (TAFI) and the risk of recurrent venous thromboembolism
From the Department of Internal Medicine I, Div. of Hematology/Hemostasis (SE, VS, AW, PAK), the Ludwig-Boltzmann Institute for Thrombosis Research (SE, PAK), and the Department of Internal Medicine II, Div. of Angiology (EM), all University of Vienna, Vienna; the Wilhelminenspital, Department of Dermatology (CB), Vienna; the Hanuschkrankenhaus, Department of Angiology (MH), Vienna; the Institu...
متن کاملThrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice.
In order to examine the physiological role of thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI deficient mice by targeted gene disruption. Intercrossing of heterozygous TAFI mice showed that TAFI mice were born in the expected Mendelian ratio, indicating that transmission of the mutant TAFI allele did not lead to embryonic lethality. TAFI deficient mice developed...
متن کاملThrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis.
Thrombin activatable fibrinolysis inhibitor (TAFI, or procarboxypeptidase B) is the precursor of a recently described carboxypeptidase that potently attenuates fibrinolysis. Therefore, we hypothesized that elevated plasma TAFI levels induce a hypofibrinolytic state associated with an increased risk for venous thrombosis. To evaluate this hypothesis, we developed an electroimmunoassay for TAFI a...
متن کاملThrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.
To investigate the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI-deficient mice by targeted gene disruption. Intercrossing of heterozygous TAFI mice produced offspring in the expected Mendelian ratio, indicating that transmission of the mutant TAFI allele did not lead to embryonic lethality. TAFI-deficient mice developed normally, ...
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تاریخ انتشار 2004